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Rational Design of [Co(acacen)L(2)](+) Inhibitors of Protein Function
Cobalt(III) Schiff base complexes, such as [Co(acacen)L(2)](+), inhibit the function of Zn(II)-dependent proteins through dissociative exchange of the axial ligands with key histidine residues of the target protein. Consequently the efficacy of these compounds depends strongly on the lability of the...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3581327/ https://ncbi.nlm.nih.gov/pubmed/23340849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2dt32565a |
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