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Effects of Uremic Toxins on Transport and Metabolism of Different Biopharmaceutics Drug Disposition Classification System (BDDCS) Xenobiotics

Chronic kidney disease (CKD) is recognized to cause pharmacokinetic changes in renally excreted drugs; however, pharmacokinetic changes are also reported for drugs that are non-renally eliminated. Few studies have investigated how uremic toxins may affect drug transporters and metabolizing enzymes a...

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Bibliografiske detaljer
Main Authors: Reyes, Maribel, Benet, Leslie Z.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581075/
https://ncbi.nlm.nih.gov/pubmed/21618544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.22640
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