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The Operational Multiple Dosing Half-life: A Key to Defining Drug Accumulation in Patients and to Designing Extended Release Dosage Forms
Half-life (t(1/2)) is the oldest but least well understood pharmacokinetic parameter, because most definitions are related to hypothetical 1-compartment body models that don’t describe most drugs in humans. Alternatively, terminal half-life (t(1/2,z)) is utilized as the single defining t(1/2) for mo...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3581066/ https://ncbi.nlm.nih.gov/pubmed/19015955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-008-9787-9 |
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