Promising Noninvasive Cellular Phenotype in Prostate Cancer Cells Knockdown of Matrix Metalloproteinase 9

Cell surface interaction of CD44 and MMP9 increases migration and invasion of PC3 cells. We show here that stable knockdown of MMP9 in PC3 cells switches CD44 isoform expression from CD44s to CD44v6 which is more glycosylated. These cells showed highly adhesive morphology with extensive cell spreadi...

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Bibliografiske detaljer
Main Authors: Gupta, Aditi, Cao, Wei, Sadashivaiah, Kavitha, Chen, Wantao, Schneider, Abraham, Chellaiah, Meenakshi A.
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580924/
https://ncbi.nlm.nih.gov/pubmed/23476138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/493689
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