IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1β-mediated degradation of nucleus pulposus in vitro

INTRODUCTION: Inflammation plays a key role in the progression of intervertebral disc degeneration, a condition strongly implicated as a cause of lower back pain. The objective of this study was to investigate the therapeutic potential of poly(lactic-co-glycolic acid) (PLGA) microspheres loaded with...

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Hlavní autoři: Gorth, Deborah J, Mauck, Robert L, Chiaro, Joseph A, Mohanraj, Bhavana, Hebela, Nader M, Dodge, George R, Elliott, Dawn M, Smith, Lachlan J
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580573/
https://ncbi.nlm.nih.gov/pubmed/22863285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3932
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