The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy

INTRODUCTION: Fibrosis in scleroderma is associated with collagen deposition and myofibroblast accumulation. Peroxisome proliferator activated receptor gamma (PPAR-γ), a master regulator of adipogenesis, inhibits profibrotic responses induced by transforming growth factor-ß (TGF-β), and its expressi...

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Main Authors: Fang, Feng, Liu, Lei, Yang, Yang, Tamaki, Zenshiro, Wei, Jun, Marangoni, Roberta G, Bhattacharyya, Swati, Summer, Ross S, Ye, Boping, Varga, John
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580540/
https://ncbi.nlm.nih.gov/pubmed/23092446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4070
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