Pharmacokinetics and Pharmacodynamics of Phase II Drug Metabolizing/Antioxidant Enzymes Gene Response by Anti-cancer Agent Sulforaphane in Rat Lymphocytes

PURPOSE: This study assesses the pharmacokinetics (PK) and pharmacodynamics (PD) of Nrf2-mediated increased expression of Phase II drug metabolizing enzyme (DME) and antioxidant enzymes which represents an important component of cancer chemoprevention in rat lymphocytes following intravenous (i.v.)...

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Autors principals: Wang, Hu, Khor, Tin Oo, Yang, Qian, Huang, Ying, Wu, Tien-yuan, Saw, Constance Lay-Lay, Lin, Wen, Androulakis, Ioannis P., Kong, Ah-Ng Tony
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580178/
https://ncbi.nlm.nih.gov/pubmed/22931102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp300130k
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