Exogenous heparin binds and inhibits bone morphogenetic protein 6 biological activity

PURPOSE: The purpose of this study was to explore the effect of heparin on bone morphogenetic protein 6 (BMP6) osteogenic activity. METHODS: Western blot analysis was used to confirm the binding of BMP6 to heparin and to observe its effect on BMP6 signaling in C2C12-BRE-Luc myoblasts. Real-time RT-P...

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Main Authors: Brkljacic, Jelena, Pauk, Martina, Erjavec, Igor, Cipcic, Antonio, Grgurevic, Lovorka, Zadro, Renata, Inman, Gareth J., Vukicevic, Slobodan
格式: Artigo
語言:Inglês
出版: Springer-Verlag 2013
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Original Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580086/
https://ncbi.nlm.nih.gov/pubmed/23307015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00264-012-1714-3
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