MEPE-Derived ASARM Peptide Inhibits Odontogenic Differentiation of Dental Pulp Stem Cells and Impairs Mineralization in Tooth Models of X-Linked Hypophosphatemia

Mutations in PHEX (phosphate-regulating gene with homologies to endopeptidases on the X-chromosome) cause X-linked familial hypophosphatemic rickets (XLH), a disorder having severe bone and tooth dentin mineralization defects. The absence of functional PHEX leads to abnormal accumulation of ASARM (a...

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Autors principals: Salmon, Benjamin, Bardet, Claire, Khaddam, Mayssam, Naji, Jiar, Coyac, Benjamin R., Baroukh, Brigitte, Letourneur, Franck, Lesieur, Julie, Decup, Franck, Le Denmat, Dominique, Nicoletti, Antonino, Poliard, Anne, Rowe, Peter S., Huet, Eric, Vital, Sibylle Opsahl, Linglart, Agnès, McKee, Marc D., Chaussain, Catherine
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579870/
https://ncbi.nlm.nih.gov/pubmed/23451077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056749
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