MEPE-Derived ASARM Peptide Inhibits Odontogenic Differentiation of Dental Pulp Stem Cells and Impairs Mineralization in Tooth Models of X-Linked Hypophosphatemia

Mutations in PHEX (phosphate-regulating gene with homologies to endopeptidases on the X-chromosome) cause X-linked familial hypophosphatemic rickets (XLH), a disorder having severe bone and tooth dentin mineralization defects. The absence of functional PHEX leads to abnormal accumulation of ASARM (a...

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Main Authors: Salmon, Benjamin, Bardet, Claire, Khaddam, Mayssam, Naji, Jiar, Coyac, Benjamin R., Baroukh, Brigitte, Letourneur, Franck, Lesieur, Julie, Decup, Franck, Le Denmat, Dominique, Nicoletti, Antonino, Poliard, Anne, Rowe, Peter S., Huet, Eric, Vital, Sibylle Opsahl, Linglart, Agnès, McKee, Marc D., Chaussain, Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579870/
https://ncbi.nlm.nih.gov/pubmed/23451077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056749
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