Phagocytosis Is the Main CR3-Mediated Function Affected by the Lupus-Associated Variant of CD11b in Human Myeloid Cells

The CD11b/CD18 integrin (complement receptor 3, CR3) is a surface receptor on monocytes, neutrophils, macrophages and dendritic cells that plays a crucial role in several immunological processes including leukocyte extravasation and phagocytosis. The minor allele of a non-synonymous CR3 polymorphism...

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Main Authors: Fossati-Jimack, Liliane, Ling, Guang Sheng, Cortini, Andrea, Szajna, Marta, Malik, Talat H., McDonald, Jacqueline U., Pickering, Matthew C., Cook, H. Terence, Taylor, Philip R., Botto, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579793/
https://ncbi.nlm.nih.gov/pubmed/23451151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057082
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