Vitamin and antioxidant rich diet increases MLH1 promoter DNA methylation in DMT2 subjects

BACKGROUND: Oxidative stress may lead to an increased level of unrepaired cellular DNA damage, which is discussed as one risk for tumor initiation. Mismatch repair (MMR) enzymes act as proofreading complexes that maintain the genomic integrity and MMR-deficient cells show an increased mutation rate....

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Библиографические подробности
Главные авторы: Switzeny, Olivier J, Müllner, Elisabeth, Wagner, Karl-Heinz, Brath, Helmut, Aumüller, Eva, Haslberger, Alexander G
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2012
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579724/
https://ncbi.nlm.nih.gov/pubmed/23025454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1868-7083-4-19
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