A virus-like particle vaccine platform elicits heightened and hastened local lung mucosal antibody production after a single dose

We show that a model antigen, ovalbumin (OVA), can be chemically conjugated to the exterior of a small heat shock protein (sHsp) cage that has structural similarities to virus-like particles (VLPs). OVA–sHsp conjugation efficiency was dependent upon the stoichiometry and the length of the small mole...

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Main Authors: Richert, Laura E., Servid, Amy E., Harmsen, Ann L., Rynda-Apple, Agnieszka, Han, Soo, Wiley, James A., Douglas, Trevor, Harmsen, Allen G.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier Ltd. 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579574/
https://ncbi.nlm.nih.gov/pubmed/22465748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2012.03.035
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