Tanshinone IIA Inhibits Hypoxia-Induced Pulmonary Artery Smooth Muscle Cell Proliferation via Akt/Skp2/p27-Associated Pathway

We previously showed that tanshinone IIA ameliorated the hypoxia-induced pulmonary hypertension (HPH) partially by attenuating pulmonary artery remodeling. The hypoxia-induced proliferation of pulmonary artery smooth muscle cells (PASMCs) is one of the major causes for pulmonary arterial remodeling,...

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Detalhes bibliográficos
Main Authors: Luo, Ying, Xu, Dun-Quan, Dong, Hai-Ying, Zhang, Bo, Liu, Yi, Niu, Wen, Dong, Ming-Qing, Li, Zhi-Chao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578942/
https://ncbi.nlm.nih.gov/pubmed/23437233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056774
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