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Properties and Modeling of GWAS when Complex Disease Risk Is Due to Non-Complementing, Deleterious Mutations in Genes of Large Effect

Current genome-wide association studies (GWAS) have high power to detect intermediate frequency SNPs making modest contributions to complex disease, but they are underpowered to detect rare alleles of large effect (RALE). This has led to speculation that the bulk of variation for most complex diseas...

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Détails bibliographiques
Auteurs principaux: Thornton, Kevin R., Foran, Andrew J., Long, Anthony D.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578756/
https://ncbi.nlm.nih.gov/pubmed/23437004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003258
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