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Zinc finger function of HIV-1 nucleocapsid protein is required for removal of 5′-terminal genomic RNA fragments: A paradigm for RNA removal reactions in HIV-1 reverse transcription
During (−) strong-stop DNA [(−) SSDNA] synthesis, RNase H cleavage of genomic viral RNA generates small 5′-terminal RNA fragments (14–18 nt) that remain annealed to the DNA. Unless these fragments are removed, the minus-strand transfer reaction, required for (−) SSDNA elongation, cannot occur. Here,...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3578084/ https://ncbi.nlm.nih.gov/pubmed/23149014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2012.08.013 |
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