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Acute tolerance to chlordiazepoxide qualitatively changes the interaction between flumazenil and pregnanolone and not the interaction between flumazenil and midazolam in rhesus monkeys discriminating midazolam

Benzodiazepines and neuroactive steroids act at distinct binding sites on γ-aminobutyric acid(A) (GABA(A)) receptors where they positively modulate GABA, resulting in similar acute behavioral effects. Tolerance to benzodiazepines can develop with repeated treatment; however, cross tolerance to neuro...

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Detalhes bibliográficos
Main Authors: Zanettini, Claudio, Yoon, Seong Shoon, France, Charles P., Gerak, Lisa R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578055/
https://ncbi.nlm.nih.gov/pubmed/23305839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2012.12.028
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