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Quantitative Analyses of Antagonism: Combinations of Midazolam and Either Flunitrazepam or Pregnanolone in Rhesus Monkeys Discriminating Midazolam

Adverse effects of benzodiazepines limit their clinical use; these effects might be reduced without altering therapeutic effects by administering other positive GABA(A) modulators (i.e., neuroactive steroids) with benzodiazepines. One concern with this strategy involves reversing these combined effe...

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Detalhes bibliográficos
Main Authors: Gerak, Lisa R., France, Charles P.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286322/
https://ncbi.nlm.nih.gov/pubmed/22173893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.188250
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