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Tandem Mass Spectrometry for Characterization of Covalent Adducts of DNA with Anti-cancer Therapeutics

The chemotherapeutic activities of many anticancer and antibacterial drugs arise from their interactions with nucleic acid substrates. Some of these ligands interact with DNA in a way that causes conformational changes or damage to the nucleic acid targets, ultimately altering recognition by key DNA...

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書目詳細資料
Main Authors: Silvestri, Catherine, Brodbelt, Jennifer S.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578003/
https://ncbi.nlm.nih.gov/pubmed/23150278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mas.21363
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