Interferon-α Is the Primary Plasma Type-I IFN in HIV-1 Infection and Correlates with Immune Activation and Disease Markers

Type-I interferon (IFN-I) has been increasingly implicated in HIV-1 pathogenesis. Various studies have shown elevated IFN-I and an IFN-I-induced gene and protein expression signature in HIV-1 infection, yet the elevated IFN-I species has not been conclusively identified, its source remains obscure a...

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Hauptverfasser: Hardy, Gareth A. D., Sieg, Scott, Rodriguez, Benigno, Anthony, Donald, Asaad, Robert, Jiang, Wei, Mudd, Joseph, Schacker, Timothy, Funderburg, Nicholas T., Pilch-Cooper, Heather A., Debernardo, Robert, Rabin, Ronald L., Lederman, Michael M., Harding, Clifford V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577907/
https://ncbi.nlm.nih.gov/pubmed/23437155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056527
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