Bmi1 Enhances Tumorigenicity and Cancer Stem Cell Function in Pancreatic Adenocarcinoma

BACKGROUND: Bmi1 is an integral component of the Polycomb Repressive Complex 1 (PRC1) and is involved in the pathogenesis of multiple cancers. It also plays a key role in the functioning of endogenous stem cells and cancer stem cells. Previous work implicated a role for cancer stem cells in the path...

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Main Authors: Proctor, Erica, Waghray, Meghna, Lee, Cheong Jun, Heidt, David G., Yalamanchili, Malica, Li, Chenwei, Bednar, Filip, Simeone, Diane M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577834/
https://ncbi.nlm.nih.gov/pubmed/23437065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055820
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