Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer

BACKGROUND: Estrogen receptor-α (ERα)-negative breast cancer is clinically aggressive and normally does not respond to conventional estrogen target-directed therapies. The soybean isoflavone, genistein (GE), has been shown to prevent and inhibit breast cancer and recent studies have suggested that G...

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Hlavní autoři: Li, Yuanyuan, Meeran, Syed M, Patel, Shweta N, Chen, Huaping, Hardy, Tabitha M, Tollefsbol, Trygve O
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577460/
https://ncbi.nlm.nih.gov/pubmed/23379261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-9
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