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Genome Mining of a Prenylated and Immunosuppressive Polyketide from Pathogenic Fungi

[Image: see text] Activation of the polycyclic polyketide prenyltransferases (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylate...

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Détails bibliographiques
Auteurs principaux: Chooi, Yit-Heng, Fang, Jinxu, Liu, Hong, Filler, Scott G., Wang, Pin, Tang, Yi
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576815/
https://ncbi.nlm.nih.gov/pubmed/23368997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol303435y
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