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Genome Mining of a Prenylated and Immunosuppressive Polyketide from Pathogenic Fungi
[Image: see text] Activation of the polycyclic polyketide prenyltransferases (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylate...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3576815/ https://ncbi.nlm.nih.gov/pubmed/23368997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol303435y |
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