Association Equilibrium of the HIV-1 Capsid Protein in a Crowded Medium Reveals that Hexamerization during Capsid Assembly Requires a Functional C-Domain Dimerization Interface

Polymerization of the intact capsid protein (CA) of HIV-1 into mature capsidlike particles at physiological ionic strength in vitro requires macromolecularly crowded conditions that approach those inside the virion, where the mature capsid is assembled in vivo. The capsid is organized as a hexameric...

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Detalhes bibliográficos
Main Authors: Bocanegra, Rebeca, Alfonso, Carlos, Rodríguez-Huete, Alicia, Fuertes, Miguel Ángel, Jiménez, Mercedes, Rivas, Germán, Mateu, Mauricio G.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Proteins and Nucleic Acids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576522/
https://ncbi.nlm.nih.gov/pubmed/23442967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.12.035
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