A Force-Activated Trip Switch Triggers Rapid Dissociation of a Colicin from Its Immunity Protein

Colicins are protein antibiotics synthesised by Escherichia coli strains to target and kill related bacteria. To prevent host suicide, colicins are inactivated by binding to immunity proteins. Despite their high avidity (K(d)≈fM, lifetime ≈4 days), immunity protein release is a pre-requisite of coli...

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Détails bibliographiques
Auteurs principaux: Farrance, Oliver E., Hann, Eleanore, Kaminska, Renata, Housden, Nicholas G., Derrington, Sasha R., Kleanthous, Colin, Radford, Sheena E., Brockwell, David J.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576412/
https://ncbi.nlm.nih.gov/pubmed/23431269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001489
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