A Force-Activated Trip Switch Triggers Rapid Dissociation of a Colicin from Its Immunity Protein

Colicins are protein antibiotics synthesised by Escherichia coli strains to target and kill related bacteria. To prevent host suicide, colicins are inactivated by binding to immunity proteins. Despite their high avidity (K(d)≈fM, lifetime ≈4 days), immunity protein release is a pre-requisite of coli...

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Detalhes bibliográficos
Main Authors: Farrance, Oliver E., Hann, Eleanore, Kaminska, Renata, Housden, Nicholas G., Derrington, Sasha R., Kleanthous, Colin, Radford, Sheena E., Brockwell, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576412/
https://ncbi.nlm.nih.gov/pubmed/23431269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001489
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