The Naphthoquinone Diospyrin Is an Inhibitor of DNA Gyrase with a Novel Mechanism of Action

Tuberculosis and other bacterial diseases represent a significant threat to human health. The DNA topoisomerases are excellent targets for chemotherapy, and DNA gyrase in particular is a well-validated target for antibacterial agents. Naphthoquinones (e.g. diospyrin and 7-methyljuglone) have been sh...

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Detalhes bibliográficos
Main Authors: Karkare, Shantanu, Chung, Terence T. H., Collin, Frederic, Mitchenall, Lesley A., McKay, Adam R., Greive, Sandra J., Meyer, Jacobus J. M., Lall, Namrita, Maxwell, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576119/
https://ncbi.nlm.nih.gov/pubmed/23275348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.419069
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