Nitric-oxide Synthase-2 Linkage to Focal Adhesion Kinase in Neutrophils Influences Enzyme Activity and β(2) Integrin Function

This investigation was to elucidate the basis for augmentation of nitric-oxide synthesis in neutrophils exposed to hyperbaric oxygen. Hyperoxia increases synthesis of reactive species leading to S-nitrosylation of β-actin, which causes temporary inhibition of β(2) integrin adherence. Impaired β(2) i...

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Autors principals: Thom, Stephen R., Bhopale, Veena M., Milovanova, Tatyana N., Yang, Ming, Bogush, Marina, Buerk, Donald G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576086/
https://ncbi.nlm.nih.gov/pubmed/23297409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.426353
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