RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR

Stimulation of epidermal growth factor receptor (EGFR) initiates RAS signaling simultaneously with EGFR internalization. Endocytosed EGFR is then either recycled or degraded. EGFR fate is determined in part by the RAS effector RIN1, a guanine nucleotide exchange factor (GEF) for RAB5 GTPases. EGFR d...

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Main Authors: Balaji, Kavitha, Mooser, Chelsea, Janson, Christine M., Bliss, Joanne M., Hojjat, Houmehr, Colicelli, John
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575715/
https://ncbi.nlm.nih.gov/pubmed/22976291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.113688
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