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Diaphanous homolog 3 (Diap3) Overexpression Causes Progressive Hearing Loss and Inner Hair Cell Defects in a Transgenic Mouse Model of Human Deafness

We previously demonstrated that a mutation in the 5′ untranslated region of Diaphanous homolog 3 (DIAPH3) results in 2 to 3-fold overexpression of the gene, leading to a form of delayed onset, progressive human deafness known as AUNA1 (auditory neuropathy, nonsyndromic, autosomal dominant, 1). To in...

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Bibliografiske detaljer
Main Authors: Schoen, Cynthia J., Burmeister, Margit, Lesperance, Marci M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575478/
https://ncbi.nlm.nih.gov/pubmed/23441200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056520
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