Enhanced Effectivity of an ALK5-Inhibitor after Cell-Specific Delivery to Hepatic Stellate Cells in Mice with Liver Injury

Transforming growth factor-β (TGF-β) is a major pro-fibrotic cytokine, causing the overproduction of extracellular matrix molecules in many fibrotic diseases. Inhibition of its type-I receptor (ALK5) has been shown to effectively inhibit fibrosis in animal models. However, apart from its pro-fibroti...

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Main Authors: van Beuge, Marike Marjolijn, Prakash, Jai, Lacombe, Marie, Post, Eduard, Reker-Smit, Catharina, Beljaars, Leonie, Poelstra, Klaas
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575413/
https://ncbi.nlm.nih.gov/pubmed/23441194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056442
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