Human Concentrative Nucleoside Transporter 3 Transfection with Ultrasound and Microbubbles in Nucleoside Transport Deficient HEK293 Cells Greatly Increases Gemcitabine Uptake

Gemcitabine is a hydrophilic clinical anticancer drug that requires nucleoside transporters to cross plasma membranes and enter cells. Pancreatic adenocarcinomas with low levels of nucleoside transporters are generally resistant to gemcitabine and are currently a clinical problem. We tested whether...

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Detalhes bibliográficos
Main Authors: Paproski, Robert J., Yao, Sylvia Y. M., Favis, Nicole, Evans, David, Young, James D., Cass, Carol E., Zemp, Roger J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575408/
https://ncbi.nlm.nih.gov/pubmed/23441192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056423
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