Ultra-high resolution HLA genotyping and allele discovery by highly multiplexed cDNA amplicon pyrosequencing

BACKGROUND: High-resolution HLA genotyping is a critical diagnostic and research assay. Current methods rarely achieve unambiguous high-resolution typing without making population-specific frequency inferences due to a lack of locus coverage and difficulty in exon-phase matching. Achieving high-reso...

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Detalhes bibliográficos
Main Authors: Lank, Simon M, Golbach, Brittney A, Creager, Hannah M, Wiseman, Roger W, Keskin, Derin B, Reinherz, Ellis L, Brusic, Vladimir, O’Connor, David H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575390/
https://ncbi.nlm.nih.gov/pubmed/22866951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-13-378
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