Tumor-derived granulocyte-macrophage colony stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer

Cancer-associated inflammation is thought to be a barrier to immune surveillance, particularly in pancreatic ductal adenocarcinoma (PDA). Gr-1(+) CD11b(+) cells are a key feature of cancer inflammation in PDA, but remain poorly understood. Using a genetically engineered mouse model of PDA, we show t...

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Detalhes bibliográficos
Main Authors: Bayne, Lauren J., Beatty, Gregory L., Jhala, Nirag, Clark, Carolyn E., Rhim, Andrew D., Stanger, Ben Z., Vonderheide, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575028/
https://ncbi.nlm.nih.gov/pubmed/22698406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.04.025
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