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Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening
Natural product discovery by random screening of broth extracts derived from cultured bacteria often suffers from high rates of redundant isolation, making it ever more challenging to identify novel biologically interesting natural products. Here we show that homology-based screening of soil metagen...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3574908/ https://ncbi.nlm.nih.gov/pubmed/23302687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218073110 |
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