A Novel Peptide-Based SILAC Method to Identify the Posttranslational Modifications Provides Evidence for Unconventional Ubiquitination in the ER-Associated Degradation Pathway

The endoplasmic reticulum-associated degradation (ERAD) pathway is responsible for disposing misfolded proteins from the endoplasmic reticulum by inducing their ubiquitination and degradation. Ubiquitination is conventionally observed on lysine residues and has been demonstrated on cysteine residues...

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Hauptverfasser: Anania, Veronica G., Bustos, Daisy J., Lill, Jennie R., Kirkpatrick, Donald S., Coscoy, Laurent
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574754/
https://ncbi.nlm.nih.gov/pubmed/23431445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/857918
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