A Novel Peptide-Based SILAC Method to Identify the Posttranslational Modifications Provides Evidence for Unconventional Ubiquitination in the ER-Associated Degradation Pathway

The endoplasmic reticulum-associated degradation (ERAD) pathway is responsible for disposing misfolded proteins from the endoplasmic reticulum by inducing their ubiquitination and degradation. Ubiquitination is conventionally observed on lysine residues and has been demonstrated on cysteine residues...

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Detalhes bibliográficos
Main Authors: Anania, Veronica G., Bustos, Daisy J., Lill, Jennie R., Kirkpatrick, Donald S., Coscoy, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574754/
https://ncbi.nlm.nih.gov/pubmed/23431445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/857918
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