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Discovery and Evaluation of Novel Inhibitors of Mycobacterium Protein Tyrosine Phosphatase B from the 6-Hydroxy-Benzofuran-5-Carboxylic Acid Scaffold

Mycobacterium tuberculosis (Mtb) protein tyrosine phosphatase B (mPTPB) is a virulence factor secreted by the pathogen and mediates mycobacterial survival in macrophages by targeting host cell immune responses. Consequently, mPTPB represents an exciting new target to combat TB infection. We describe...

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Autors principals: He, Yantao, Xu, Jie, Yu, Zhi-hong, Gunawan, Andrea M., Wu, Li, Wang, Lina, Zhang, Zhong-Yin
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574584/
https://ncbi.nlm.nih.gov/pubmed/23305444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301781p
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