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Viral mutation rates: modelling the roles of within-host viral dynamics and the trade-off between replication fidelity and speed

Many viruses, particularly RNA viruses, mutate at a very high rate per genome per replication. One possible explanation is that high mutation rates are selected to meet the challenge of fluctuating environments, including the host immune response. Alternatively, recent studies argue that viruses evo...

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Detalhes bibliográficos
Main Authors: Regoes, Roland R., Hamblin, Steven, Tanaka, Mark M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574426/
https://ncbi.nlm.nih.gov/pubmed/23135674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rspb.2012.2047
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