Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway

Neutrophil apoptosis and subsequent nonphlogistic clearance by surrounding phagocytes are key to the successful resolution of neutrophilic inflammation, with dysregulated apoptosis reported in multiple human inflammatory diseases. Enhancing neutrophil apoptosis has proresolution and anti-inflammator...

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Detalhes bibliográficos
Main Authors: Lucas, Christopher D., Allen, Keith C., Dorward, David A., Hoodless, Laura J., Melrose, Lauren A., Marwick, John A., Tucker, Carl S., Haslett, Christopher, Duffin, Rodger, Rossi, Adriano G.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574292/
https://ncbi.nlm.nih.gov/pubmed/23195034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-218990
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