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When the Brakes are Lost: LNK Dysfunction in Mice, Men, and Myeloproliferative Neoplasms
Aberrant JAK-STAT signaling is a hallmark of myeloproliferative neoplasms (MPNs). These hyperproliferative disorders are classically associated with activating mutations in tyrosine kinases such as JAK2 and the thrombopoietin (TPO) receptor MPL. Activation of JAK-STAT signaling and responses to JAK2...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SAGE Publications
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3573389/ https://ncbi.nlm.nih.gov/pubmed/23556072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2040620710393391 |
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