Oxidative stress, fibrosis, and early afterdepolarization-mediated cardiac arrhythmias

Animal and clinical studies have demonstrated that oxidative stress, a common pathophysiological factor in cardiac disease, reduces repolarization reserve by enhancing the L-type calcium current, the late Na, and the Na-Ca exchanger, promoting early afterdepolarizations (EADs) that can initiate vent...

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Bibliographic Details
Main Authors: Karagueuzian, Hrayr S., Nguyen, Thao P., Qu, Zhilin, Weiss, James N.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2013
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3573324/
https://ncbi.nlm.nih.gov/pubmed/23423152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2013.00019
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