The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC

In hereditary diffuse gastric cancer (HDGC), CDH1 germline gene alterations are causative events in 30% of the cases. In 20% of HDGC families, CDH1 germline mutations are of the missense type and the mutation carriers constitute a problem in terms of genetic counseling and surveillance. To access th...

Full description

Saved in:
Bibliographic Details
Main Authors: Figueiredo, Joana, Söderberg, Ola, Simões-Correia, Joana, Grannas, Karin, Suriano, Gianpaolo, Seruca, Raquel
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3573198/
https://ncbi.nlm.nih.gov/pubmed/22850631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2012.159
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items