Allosteric Regulation of Serine Protease HtrA2 through Novel Non-Canonical Substrate Binding Pocket

HtrA2, a trimeric proapoptotic serine protease is involved in several diseases including cancer and neurodegenerative disorders. Its unique ability to mediate apoptosis via multiple pathways makes it an important therapeutic target. In HtrA2, C-terminal PDZ domain upon substrate binding regulates it...

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Detaylı Bibliyografya
Asıl Yazarlar: Bejugam, Pruthvi Raj, Kuppili, Raja R., Singh, Nitu, Gadewal, Nikhil, Chaganti, Lalith K., Sastry, G. Madhavi, Bose, Kakoli
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3573033/
https://ncbi.nlm.nih.gov/pubmed/23457469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055416
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