Allosteric Regulation of Serine Protease HtrA2 through Novel Non-Canonical Substrate Binding Pocket

HtrA2, a trimeric proapoptotic serine protease is involved in several diseases including cancer and neurodegenerative disorders. Its unique ability to mediate apoptosis via multiple pathways makes it an important therapeutic target. In HtrA2, C-terminal PDZ domain upon substrate binding regulates it...

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Detalhes bibliográficos
Main Authors: Bejugam, Pruthvi Raj, Kuppili, Raja R., Singh, Nitu, Gadewal, Nikhil, Chaganti, Lalith K., Sastry, G. Madhavi, Bose, Kakoli
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3573033/
https://ncbi.nlm.nih.gov/pubmed/23457469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055416
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