Allosteric Regulation of Serine Protease HtrA2 through Novel Non-Canonical Substrate Binding Pocket

HtrA2, a trimeric proapoptotic serine protease is involved in several diseases including cancer and neurodegenerative disorders. Its unique ability to mediate apoptosis via multiple pathways makes it an important therapeutic target. In HtrA2, C-terminal PDZ domain upon substrate binding regulates it...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Bejugam, Pruthvi Raj, Kuppili, Raja R., Singh, Nitu, Gadewal, Nikhil, Chaganti, Lalith K., Sastry, G. Madhavi, Bose, Kakoli
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3573033/
https://ncbi.nlm.nih.gov/pubmed/23457469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055416
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