Production of β-globin and adult hemoglobin following G418 treatment of erythroid precursor cells from homozygous β(0)39 thalassemia patients

In several types of thalassemia (including β(0)39-thalassemia), stop codon mutations lead to premature translation termination and to mRNA destabilization through nonsense-mediated decay. Drugs (for instance aminoglycosides) can be designed to suppress premature termination, inducing a ribosomal rea...

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Bibliografiska uppgifter
Huvudupphovsmän: Salvatori, Francesca, Breveglieri, Giulia, Zuccato, Cristina, Finotti, Alessia, Bianchi, Nicoletta, Borgatti, Monica, Feriotto, Giordana, Destro, Federica, Canella, Alessandro, Brognara, Eleonora, Lampronti, Ilaria, Breda, Laura, Rivella, Stefano, Gambari, Roberto
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572903/
https://ncbi.nlm.nih.gov/pubmed/19810011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.21539
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