Saccharomyces cerevisiae Apn1 Mutation Affecting Stable Protein Expression Mimics Catalytic Activity Impairment: Implications for Assessing DNA Repair Capacity in Humans

Apurinic/apyrimidinic (AP) endonucleases play a major role in the repair of AP sites, oxidative damage and alkylation damage in DNA. We employed Saccharomyces cerevisiae in an unbiased forward genetic screen to identify amino acid substitutions in the major yeast AP endonuclease, Apn1, that impair c...

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Hauptverfasser: Morris, Lydia P., Degtyareva, Natalya, Sheppard, Clayton, Heyburn, Lanier, Ivanov, Andrei A., Kow, Yoke Wah, Doetsch, Paul W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572540/
https://ncbi.nlm.nih.gov/pubmed/22818187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.06.008
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