Saccharomyces cerevisiae Apn1 Mutation Affecting Stable Protein Expression Mimics Catalytic Activity Impairment: Implications for Assessing DNA Repair Capacity in Humans

Apurinic/apyrimidinic (AP) endonucleases play a major role in the repair of AP sites, oxidative damage and alkylation damage in DNA. We employed Saccharomyces cerevisiae in an unbiased forward genetic screen to identify amino acid substitutions in the major yeast AP endonuclease, Apn1, that impair c...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Morris, Lydia P., Degtyareva, Natalya, Sheppard, Clayton, Heyburn, Lanier, Ivanov, Andrei A., Kow, Yoke Wah, Doetsch, Paul W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572540/
https://ncbi.nlm.nih.gov/pubmed/22818187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.06.008
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados