Saccharomyces cerevisiae Apn1 Mutation Affecting Stable Protein Expression Mimics Catalytic Activity Impairment: Implications for Assessing DNA Repair Capacity in Humans

Apurinic/apyrimidinic (AP) endonucleases play a major role in the repair of AP sites, oxidative damage and alkylation damage in DNA. We employed Saccharomyces cerevisiae in an unbiased forward genetic screen to identify amino acid substitutions in the major yeast AP endonuclease, Apn1, that impair c...

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Main Authors: Morris, Lydia P., Degtyareva, Natalya, Sheppard, Clayton, Heyburn, Lanier, Ivanov, Andrei A., Kow, Yoke Wah, Doetsch, Paul W.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572540/
https://ncbi.nlm.nih.gov/pubmed/22818187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.06.008
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