Saccharomyces cerevisiae Apn1 Mutation Affecting Stable Protein Expression Mimics Catalytic Activity Impairment: Implications for Assessing DNA Repair Capacity in Humans

Apurinic/apyrimidinic (AP) endonucleases play a major role in the repair of AP sites, oxidative damage and alkylation damage in DNA. We employed Saccharomyces cerevisiae in an unbiased forward genetic screen to identify amino acid substitutions in the major yeast AP endonuclease, Apn1, that impair c...

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Detaylı Bibliyografya
Asıl Yazarlar: Morris, Lydia P., Degtyareva, Natalya, Sheppard, Clayton, Heyburn, Lanier, Ivanov, Andrei A., Kow, Yoke Wah, Doetsch, Paul W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572540/
https://ncbi.nlm.nih.gov/pubmed/22818187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.06.008
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