Exon-Skipping Strategy by Ratio Modulation between Cytoprotective versus Pro-Apoptotic Clusterin Forms Increased Sensitivity of LNCaP to Cell Death

BACKGROUND: In prostate cancer the secreted form of clusterin (sCLU) has been described as an anti-apoptotic protein whose expression is increased after therapeutic intervention, whereas, the nuclear protein form nCLU was reported to have pro-apoptotic properties. METHODOLOGY: In order to provide ne...

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Bibliografiske detaljer
Main Authors: Essabbani, Abdellatif, Garcia, Luis, Zonetti, Maria Josè, Fisco, Tommaso, Pucci, Sabina, Chiocchia, Gilles
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572101/
https://ncbi.nlm.nih.gov/pubmed/23418433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054920
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