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A Synthetic Recursive “+1” Pathway for Carbon Chain Elongation
Nature uses four methods of carbon chain elongation for the production of 2-ketoacids, fatty acids, polyketides, and isoprenoids. Using a combination of quantum mechanical (QM) modeling, protein–substrate modeling, and protein and metabolic engineering, we have engineered the enzymes involved in leu...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3571861/ https://ncbi.nlm.nih.gov/pubmed/22242720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200313e |
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