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Fatty Acid Chain Elongation in Palmitate-perfused Working Rat Heart: MITOCHONDRIAL ACETYL-CoA IS THE SOURCE OF TWO-CARBON UNITS FOR CHAIN ELONGATION
Rat hearts were perfused with [1,2,3,4-(13)C(4)]palmitic acid (M+4), and the isotopic patterns of myocardial acylcarnitines and acyl-CoAs were analyzed using ultra-HPLC-MS/MS. The 91.2% (13)C enrichment in palmitoylcarnitine shows that little endogenous (M+0) palmitate contributed to its formation....
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3974991/ https://ncbi.nlm.nih.gov/pubmed/24558043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.524314 |
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